Cellevate is an innovative biotech company that develops the next generation of cell culture systems. We create highly porous and consistent networks of nanofibers through a patented manufacturing process. Cells in these networks are allowed to proliferate and interact with other cells in three dimensions (3D), in contrast to the monolayer cultures seen on conventional two dimensional (2D) surfaces. Our goal is to provide life science researchers with more realistic in-vitro models, for more relevant data and successful research.
A 3D cell culture is an artificially-created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. Unlike 2D environments (e.g. a petri dish), a 3D cell culture allows cells in vitro to grow in all directions, similar to how they would in vivo.
Cellevates nanofiber scaffolds for 3D cell culture are produced through our own patented technique. We have revised the standard electrospinning method used to create most of our competitions products and improved it with regard to scaffold parameter control (and consequently overall fiber quality) and batch-to-batch consistency.Learn More
Cellevate 3D cell culture scaffolds consists of highly porous and consistent networks of biocompatible nanofibers. The fibers provide an environment which mimic the complex surroundings cells experience in their native tissues and provides life science researchers with a more realistic in-vitro models.
â€ťCulturing of cancer cell lines in 2D in tissue culture plastic has taught us a lot about cancer on the cellular and molecular levels. However, in the body, cells do not grow in a 2D environment but in 3D where the interaction with other cells has a far greater impact on cell behaviour than we previously thought. Thus, to further increase our understanding of cancer, we need to cultivate cancer cells in 3D and not only cancer cells on their own but together with stromal cells. A further important step is to use totally defined components in the cell culture systems and as far as possible reduce animal-derived products. For this purpose, we are using Cellevates 3D Nanomatrixâ„˘ electrospun polycaprolactone fibers in a 3D mesh mimicing collagen together with various recombinatly-derived extra cellular matrix components forming a hydrogel in which the cells are cultivated.â€ť
- Professor, Department of Biology, Lund University
â€śThe 3D fibrous scaffolds provided by Cellevate have helped us discover important topographical effects on neural stem cell behavior in vitro. The scaffolds allow long-term culture of different types of neural cell, as well as support and guidance of neuronal development into functional neural networksâ€ť
- Senior Researcher in Neurobiology, Medical faculty, Lund University
"It is very important for my research that the properties of the products i use are reproducible and have a high batch-to-batch consistency. I'm happy to say Cellevates products live up to my expectations. We have in several studies shown that differentiation can be controlled by using Cellevates 3D Nanomatrixâ„˘ nanofibers, which makes them very interesting for stem cell research."
- Assistant Professor, Lund University Biomedical Center
â€śOur preliminary studies conclude that the Cellevate 3D Nanomatrixâ„˘ structures are able to support human adipose tissue-derived stem cells proliferation under standard cell culture conditions in a similar fashion to the 2D tissue culture polystyrene surface. Additionally, it seems that Cellevate 3D Nanomatrixâ„˘ structures offered an advantageous support for the osteogenic differentiation of human adipose tissue-derived stem cells in comparison to the standard 2D tissue culture polystyrene.â€ť
- Senior Researcher, 3Bâ€™s Research Group, University of Minho